Neuromuscular Disorders

  |  Neurodegenerative Diseases  |  Neuromuscular Disorders

Neuromuscular disorders occur in 1.5 million Americans each year, causing debilitating symptoms that are often progressive. These disorders happen due to damaged nerve cells and neurodegeneration.

These disorders of the myoskeletal system are due to various causes which are most often hereditary, metabolic and/or inflammatory.

Some examples of neuromuscular disorders include the following:

  • Amyotrophic lateral sclerosis
  • Muscular dystrophy
  • Severe myasthenia – Myasthenia Gravis
  • Spinal muscular atrophy

Diagnosis of Real Causes & Treatments of Neuromuscular Disorders

  • Gradual restoration of cellular function
  • Personalized therapeutic protocols, without chemical residues and excipients
  • Treating the real causes
  • Therapeutic formulas that work alone or in combination with any other medication
  • Adopting a Molecular / Therapeutic Nutrition Plan

Symptoms of neuromuscular disorders

Symptoms that affect the eyes are often the first to appear. The throat and jaw are also often affected early. This can affect speech, chewing, swallowing and head control. Symptoms also include weakness, paralysis, respiratory distress, aesthetic changes, balance difficulties and other problems that significantly affect quality of life.

What are the causes?

There are different causes for these diseases. Many of them are genetic. This means they are inherited or caused by a new mutation(s) in the genes. Some neuromuscular disorders are autoimmune diseases, while sometimes the cause is not known. For example, some genes found in the genetic material of individuals are those that make them more likely to develop the disease.

How is it diagnosed?

Neuromuscular disorders are motor unit disorders that include the lower motor neuron, the nerve root, the peripheral nerve, the myogenic joint, and the muscles. Any classification of neuromuscular disease can be somewhat arbitrary and the physician should keep in mind that the pathological process may involve several parts of the nervous system and muscles. For example, neuropathies can lead to progressive, peripheral motor and aesthetic impairment along with autonomic dysfunction. Disorders such as amyotrophic lateral sclerosis (ALS) can progress rapidly to death, while some chronic neuropathies such as Charcot-Marie-Tooth disease or autonomic syndromes such as familial dystrophy may develop more slowly.

Diagnosis as well as treatment can be extremely difficult and requires specialized physicians starting from the clinical evaluation and determination of a course of care. Diagnosing neuromuscular disease can be a complicated process. A wide range of diseases can affect the nerves and muscles and often produce similar symptoms, such as weakness and numbness. Diagnostic tests include:

  • Biochemical and genetic testing
  • Computed tomography (CT)
  • Magnetic resonance imaging (MRI)
  • Nervous and muscle biopsy
  • Conductivity studies and electromyography (EMG)

The modern medical treatment

Targeted correction of organic imbalances can be a powerful tool in the physical treatment of almost all cases of neuromuscular disorders. The clinical context that combines diet and lifestyle factors with the correction of environmental factors in the incidence of chronic disease is now the new medical approach. Every specialist physician must evaluate the imbalances at the cellular level. This helps explain why the disease has happened. By understanding each of these imbalances, the physician with the patient can make adjustments to correct the cause.

Natural treatment

There are often many factors that need to be tackled such as nutritional deficiencies, stress, poor immune function and hormone imbalances.

This is why, there are natural remedies that treat the disease through boosting the immune system, reducing inflammation and correcting nutrient deficiencies that can worsen the condition. Possible natural remedies depend on individual needs. The best course of action, understanding and examining the body holistically to identify possible causes and address them through nutritional, natural hormonal rehabilitation and complementary support.

 

References:

  • National Institute of Environmental Health Sciences. Neurodegenerative diseases. Reviewed September 10, 2019. Accessed May 18, 2020. https://www.niehs.nih.gov/research/supported/health/neurodegenerative/index.cfm
  • Swerdlow RH. Mitochondria and mitochondrial cascades in Alzheimer’s disease. J Alzheimers Dis.2018;62(3):1403-1416. doi:10.3233/JAD-170585
  • García S, Martín Giménez VM, Mocayar Marón FJ, Reiter RJ, Manucha W. Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases. Histol Histopathol. 2020:18212. doi:10.14670/HH-18-212
  • Alzheimer’s Association. Alternative treatments. Accessed May 18, 2020. https://www.alz.org/alzheimers-dementia/treatments/alternative-treatments
  • Parkinson’s Foundation. Over the counter and complementary therapies. Accessed May 18, 2020. https://www.parkinson.org/Understanding-Parkinsons/Treatment/Over-the-Counter-and-Complementary-Therapies
  • National Multiple Sclerosis Society. Complementary and alternative medicines. Accessed May 18, 2020. https://www.nationalmssociety.org/Treating-MS/Complementary-Alternative-Medicines
  • Wesselman LMP, Doorduijn AS, de Leeuw FA, et al. Dietary patterns are related to clinical characteristics in memory clinic patients with subjective cognitive decline: the SCIENCe project. Nutrients. 2019;11(5):1057.doi:10.3390/nu11051057
  • Fieldhouse JLP, Doorduijn AS, de Leeuw FA, et al. A suboptimal diet is associated with poorer cognition: the NUDAD project. Nutrients. 2020;12(3):703. doi:10.3390/nu12030703
  • Nolan JM, Mulcahy R, Power R, Moran R, Howard AN. Nutritional intervention to prevent Alzheimer’s disease: potential benefits of xanthophyll carotenoids and omega-3 fatty acids combined. J Alzheimers Dis. 2018;64(2):367-378. doi:10.3233/JAD-180160
  • Calil SRB, Brucki SMD, Nitrini R, Yassuda MS. Adherence to the Mediterranean and MIND diets is associated with better cognition in healthy seniors but not in MCI or AD. Clin Nutr ESPEN. 2018;28:201-207. doi:10.1016/j.clnesp.2018.08.001
  • Power R, Prado-Cabrero A, Mulcahy R, Howard A, Nolan JM. The role of nutrition for the aging population: implications for cognition and Alzheimer’s disease. Annu Rev Food Sci Technol. 2019;10:619-639.doi:1146/annurev-food-030216-030125
  • Chai B, Gao F, Wu R, et al. Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: anupdated meta-analysis. BMC Neurol. 2019;19(1):284. doi:10.1186/s12883-019-1500-6
  • Bianchi VE, Herrera PF, Laura R. Effect of nutrition on neurodegenerative diseases. A systematic review.Nutr Neurosci. Published online November 4, 2019. doi:10.1080/1028415X.2019.1681088
  • Grodzicki W, Dziendzikowska K. The role of selected bioactive compounds in the prevention of Alzheimer’s disease. Antioxidants. 2020;9(3):229. doi:10.3390/antiox9030229
  • AlAmmar WA, Albeesh FH, Ibrahim LM, Algindan YY, Yamani LZ, Khattab RY. Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review. Nutr Neurosci. Published online August 28, 2019. doi:10.1080/1028415X.2019.1659560
  • Wlodarek D. Role of ketogenic diets in neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease). Nutrients. 2019;11(1):169. doi:10.3390/nu11010169
  • Chauhan A, Chauhan V. Beneficial effects of walnuts on cognition and brain health. Nutrients. 2020;12(2):550. doi:10.3390/nu12020550
  • Valls-Pedret C, Sala-Vila A, Serra-Mir M, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med. 2015;175(7):1094-1103. doi:10.1001/jamainternmed.2015.1668
  • Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health benefits and molecular mechanisms of resveratrol: a narrative review. Foods. 2020;9(3):340. doi:10.3390/foods9030340
  • Huhn S, Beyer F, Zhang R, et al. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults – a randomized controlled trial. Neuroimage. 2018;174:177-190. doi:10.1016/j.neuroimage.2018.03.023
  • Evans HM, Howe PR, Wong RH. Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women: a 14-week randomised placebo-controlled intervention trial. Nutrients. 2017;9(1):27. doi:10.3390/nu9010027
  • Liu H, Ye M, Guo H. An updated review of randomized clinical trials testing the improvement of cognitive function of Ginkgo biloba extract in healthy people and Alzheimer’s patients. Front Pharmacol. 2020;10:1688. doi:10.3389/fphar.2019.01688
  • Power R, Coen RF, Beatty S, et al. Supplemental retinal carotenoids enhance memory in healthy individuals with low levels of macular pigment in a randomized, double-blind, placebo-controlled clinical trial. J Alzheimers Dis. 2018;61(3):947-961. doi:10.3233/JAD-170713
  • Lee DH, Chon J, Kim Y, et al. Association between vitamin D deficiency and cognitive function in the elderly Korean population: a Korean frailty and aging cohort study. Medicine (Baltimore). 2020;99(8):e19293. doi:10.1097/MD.0000000000019293
  • Feige J, Moser T, Bieler L, Schwenker K, Hauer L, Sellner J. Vitamin D supplementation in multiple sclerosis: a critical analysis of potentials and threats. Nutrients. 2020;12(3):783. doi:10.3390/nu12030783
  • Kouchaki E, Afarini M, Abolhassani J, et al. High-dose ?-3 fatty acid plus vitamin D3 supplementation affects clinical symptoms and metabolic status of patients with multiple sclerosis: a randomized controlled clinical trial. J Nutr. 2018;148(8):1380-1386. doi:10.1093/jn/nxy116
  • Martínez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84(12):1318-1325. doi:10.1136/jnnp-2012-304792
  • Lee JE, Bisht B, Hall MJ, et al. A multimodal, nonpharmacologic intervention improves mood and cognitive function in people with multiple sclerosis. J Am Coll Nutr. 2017;36(3):150-168. doi:10.1080/07315724.2016.1255160
  • Ota M, Matsuo J, Ishida I, et al. Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease. Neurosci Lett. 2019;690:232-236. doi: 10.1016/j.neulet.2018.10.048