• 14
  • May
  • 0
Progesterone
Author

Progesterone, the protector of our Nervous System

Progesterone is considered to be a predominantly “female” hormone, essential for fertility and pregnancy.

In reality, however, it is a hormone that affects both sexes. It is found in small amounts in the brains of both women and men and has multiple protective effects in the human body.

Research suggests that progesterone facilitates the proper function of the nervous system and especially the brain.

As a result of its important functions in the nervous system, progesterone has been classified as “neurosterone”.

It comes from two different parts in order to reach the brain:

  • Brain cells, the spinal cord and the peripheral nervous system which make up progesterone from cholesterol.
  • Progesterone circulating in the blood also has direct access to the brain and nerves

How does Progesterone operate in our Nervous System?

It protects our brain

Progesterone plays an important role in the development of neurons in the brain and in its protection from damage and recovery after injury.

It actually achieves this by promoting the development and repair of the myelin sheath that protects nerve fibers.

About 20 years ago, researchers studying rats after brain damage made an important observation. Female rats, which were in the reproductive cycle at the time of brain damage, when progesterone levels were at their highest, had significantly less brain damage than male rats or females with lower progesterone levels.

This research eventually led to clinical trials in humans, which have found that high doses of natural progesterone have significantly improved patients’ survival after traumatic brain injury. In particular, when it is administered shortly after brain injury, it can reduce cerebral edema and neuronal death of the brain and it could improve patients’ prognosis in terms of their neural functional abilities.

It contributes to the treatment after a stroke

A review recently published suggests that not only should progesterone be used to treat traumatic brain injuries, but that it may also play a role in the treatment of stroke, due to its strong protective effects on brain tissue.

It improves memory and cognitive ability

Progesterone, like pregnenolone and dehydroepiandrosterone (DHEA), belongs to the group of neurosteroids. It can be synthesized within the central nervous system and also serves as a precursor to another important neurosteroid hormone, allopregnanolone.

Neurosteroids affect synaptic function, are neuroprotective and affect myelination.

They have been researched for their ability to improve memory and cognitive ability.

The Bioidentical Hormone Replacement Therapy

The laboratory tests and clinical trials of the last 20 years with progesterone, promise a lot for the overall protection of our nervous system. In the above conditions, an individual’s natural hormonal recovery can not only correct the lack of progesterone (which causes a whole range of other symptoms), but can also relieve the pain which is caused by inflammation of the neurons.

 

 

Dr. Nikoleta Koini, M.D.

Doctor of Functional, Preventive, Anti-ageing and Restorative Medicine.
Diplomate and Board Certified in Anti-aging, Preventive, Functional and Regenerative Medicine from A4M (American Academy in Antiaging Medicine).

 

References:
    1. Taraborrelli S (November 2015). “Physiology, production and action of progesterone”. Acta Obstetricia et Gynecologica Scandinavica. 94 Suppl 161: 8–16. doi:10.1111/aogs.12771. PMID 26358238. S2CID 40213725.
    2. Thomas P, Pang Y (2012). “Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells”. Neuroendocrinology. 96 (2): 162–71. doi:10.1159/000339822. PMC 3489003. PMID 22687885.
    3. Ryu CS, Klein K, Zanger UM (2017-03-27). “Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450”. Frontiers in Pharmacology. 8: 159. doi:10.3389/fphar.2017.00159. PMC 5366339. PMID 28396637.
    4. Patel B, Elguero S, Thakore S, Dahoud W, Bedaiwy M, Mesiano S (2014). “Role of nuclear progesterone receptor isoforms in uterine pathophysiology”. Human Reproduction Update. 21 (2): 155–73. doi:10.1093/humupd/dmu056. PMC 4366574. PMID 25406186.
    5. Kuhl H, Schneider HP (August 2013). “Progesterone–promoter or inhibitor of breast cancer”. 16 Suppl 1: 54–68. doi:10.3109/13697137.2013.768806. PMID 23336704. S2CID 20808536.
    6. Jiang C, Zuo F, Wang Y, Wan J, Yang Z, Lu H, Chen W, Zang W, Yang Q, Wang J (June 2016). “Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice”. Neurobiology of Aging. 42: 13–24. doi:10.1016/j.neurobiolaging.2016.02.029. PMC 4857017. PMID 27143417.
    7. Luoma JI, Stern CM, Mermelstein PG (August 2012). “Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection”. The Journal of Steroid Biochemistry and Molecular Biology. 131 (1–2): 30–6. doi:10.1016/j.jsbmb.2011.11.002. PMC 3303940. PMID 22101209.
    8. Espinoza TR, Wright DW (2011). “The role of progesterone in traumatic brain injury”. The Journal of Head Trauma Rehabilitation. 26 (6): 497–9. doi:10.1097/HTR.0b013e31823088fa. PMC 6025750. PMID 22088981.
    9. Li Z, Wang B, Kan Z, Zhang B, Yang Z, Chen J, Wang D, Wei H, Zhang JN, Jiang R (January 2012). “Progesterone increases circulating endothelial progenitor cells and induces neural regeneration after traumatic brain injury in aged rats”. Journal of Neurotrauma. 29 (2): 343–53. doi:10.1089/neu.2011.1807. PMC 3261789. PMID 21534727.
    10. Filicori M (2015). “Clinical roles and applications of progesterone in reproductive medicine: an overview”. Acta Obstet Gynecol Scand. 94 Suppl 161: 3–7. doi:10.1111/aogs.12791. PMID 26443945.
    11. Ciampaglia W, Cognigni GE (2015). “Clinical use of progesterone in infertility and assisted reproduction”. Acta Obstet Gynecol Scand. 94 Suppl 161: 17–27. doi:10.1111/aogs.12770. PMID 26345161. S2CID 40753277.
    12. Choi SJ (2017). “Use of progesterone supplement therapy for prevention of preterm birth: review of literatures”. Obstet Gynecol Sci. 60 (5): 405–420. doi:10.5468/ogs.2017.60.5.405. PMC 5621069. PMID 28989916.

     

Avatar
Dr Koini

Leave a Comment